p 28: bone marrow-derived mesenchymal stem cells reduces neuroinflammation and splenic cytolytic cd8 + t cells in mice with experimental autoimmune encephalomyelitis

نویسندگان

amir ghaemi a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of virology, institute pasteur of iran, tehran, iran

leila alizadeh shefa neuroscience research center, khatam alanbia hospital, tehran, iran

gelareh vakilzadeh shefa neuroscience research center, khatam alanbia hospital, tehran, iran

soodeh razeghi jahromi multiple sclerosis research center-neuroscience institute, sina hospital, tehran university of medical sciences, tehran, iran

چکیده

introduction: multiple sclerosis (ms) has been recognized as a common neurodegenerative disease that occurs after an auto reactive t cells against myelin antigens.  demyelination and inflammation are the main features of this disease. the anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (bm-mscs) have been considered as a suitable treatment against autoimmune diseases. previous studies have shown that treatment with bm-mscs may regulate immune responses and improve the symptoms in experimental autoimmune encephalomyelitis (eae) mice, an animal model of multiple sclerosis. therefore, the present study was designed to evaluate immunomodulatory effects of bm-mscs in the treatment of myelin oligodendrocyte glycoprotein (mog) 35-55-induced eae in c57bl/6 mice. materials and methods: mscs were obtained from the bone marrow of c57bl mice, cultured with dmem/f12, and characterized with flow cytometer for the presence of cell-surface markers for bm-mscs. following three passages, bm-mscs were injected intraperitoneally into eae mice. immunological responses of the transplantation were evaluated. results: the results demonstrated that bm-mscs transplantation in eae mice significantly reduced inflammation infiltration and demyelination, enhanced the immunomodulatory functions, and inhibited progress of neurological impairments compared to control groups. conclusion: this study suggests the potential of bm-mscs to induce immunomodulatory and anti-inflammatory roles in the treatment of neuroinflammatory disorders.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P 28: Bone Marrow-Derived Mesenchymal Stem Cells Reduces Neuroinflammation and Splenic Cytolytic CD8 + T Cells in Mice with Experimental Autoimmune Encephalomyelitis

Introduction: Multiple sclerosis (MS) has been recognized as a common neurodegenerative disease that occurs after an Auto reactive T cells against myelin antigens.  Demyelination and inflammation are the main features of this disease. The anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (BM-MSCs) have been considered as a suitable tre...

متن کامل

Immunomodulatory Effect of Mesenchymal Stem Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: A Review Study

Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system that may lead to disability of the patient. Current MS treatment regimens are still insufficient and research is conducted for developing more effective therapies capable of targeting neurodegeneration, inflammation, and demyelination. Recent results of experimental and clinical studies in ...

متن کامل

Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis.

Mesenchymal stem cells (MSCs) represent a promising therapeutic approach for neurological autoimmune diseases; previous studies have shown that treatment with bone marrow-derived MSCs induces immune modulation and reduces disease severity in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Here we show that intravenous administration of adipose-derived MSC...

متن کامل

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells

Objective(s): Although many researchers have confirmed induction of germ cells from bone marrow mesenchymal stem cells (BMMSCs), there are no reports that confirm spontaneous differentiation of germ cells from BMMSCs. In this study, we have evaluated the effect of adult Sertoli cell condition medium (SCCM) as a mutative factor in the induction of germ cells from BMMSCs. Materials and Methods: ...

متن کامل

Harvesting of bone marrow mesenchymal stem cells from live rats and the in vitro differentiation of bone marrow mesenchymal stem cells into neuron-like cells

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

متن کامل

The effect of bone marrow-derived mesenchymal stem cells to induce PD-L1 molecule on splenic lymphocytes

Background: Mesenchymal stem cells are non-hematopoietic stromal cells that are used in the treatment of many chronic and autoimmune diseases by modulating the immune system. Due to the limitations of using autologous mesenchymal stem cells, the use of allogeneic stem cells is a promising therapeutic approach in the treatment of immunological disorders. This study aimed to investigate the abili...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
مجله علوم اعصاب شفای خاتم

جلد ۵، شماره ۲، صفحات ۵۹-۵۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023